Wednesday, December 19, 2007

Physical activity and health

The evidence linking inactive living with a range of physical and mental diseases and disorders is now accepted by leading authorities world wide. People need to move more and more often. Unfortunately, the majority of the population, particularly those most likely to benefit, such as the middle aged and elderly, are unlikely to become more active. Individuals should take personal responsibility and establish lifestyles that involve healthier eating and more daily physical activity.
Physical activity refers to all energy expended by movement, including everyday activities, such as walking, cycling, climbing stairs, housework, and shopping, occurring as an incidental part of our routines. Exercise, on the other hand, is a planned and purposeful attempt to improve fitness and health that might include activities such as brisk walking, cycling, aerobic dance, and perhaps active hobbies such as gardening and competitive sports such as distance running, or lifting weight
In the past 20 years or so extensive evidence has established that inactivity causes illness and premature death. Those who maintain a reasonable amount of activity, particularly across the middle and later years, are twice as likely to avoid early death and serious illness, leading to the recognition of inactivity as the fourth primary risk factor for heart disease. Further good news suggests that the process of becoming fitter produces distinct benefits and it appears that it is never too late to make some changes and experience these positive outcomes.
Physical activity has both preventive and therapeutic effects.
Coronary heart disease and stroke
Coronary heart disease remains the leading cause of death in developed countries. Maintaining an active lifestyle, and a moderately high level of aerobic fitness, halves the chances of either dying from or contracting serious heart disease. There is a clear
dose response relationship, with the change from sedentary to moderately active producing greatest health benefits. Regular walking produces a reduction in CHD events, cycling to work, active commuting to work, and four hours of recreational activity per week or at least 800 kcals of leisure time activity per week are all associated with reduced risk.
The preventive and therapeutic effects of physical activity on stroke are less clear with studies showing inconsistent results.
Obesity
Obesity appears to be a direct result of environmental conditions that involve easy access to motorized transport, labor-saving devices, home screen entertainment, and cheap, high dens
ity food.. The evidence that reduced physical activity has been a determinant of this increase is

stronger than the evidence for increased energy intake
There are several prospective studies that indicate the benefits of an active and fit
lifestyle for the prevention of obesity.. Furthermore, those who maintain exercise are much
more likely to sustain any weight loss long term than those who rely on dietary management alone.
Perhaps the greatest benefit of physical activity for the obese is its impact on health risk profile. Reviewed observational studies concluded that obese people who managed to keep active and fit reduced their risk of heart disease and diabetes relative to non-obese levels. This would suggest that it is not unhealthy to be fat as long as you remain fit. It also puts into question whether obesity is more hazardous than inactivity.
Adult onset diabetes
There is strong evidence to show that inactivity may be a causal factor on the incidence of Type 2 diabetes. Prospective studies indicate a strong negative relationship between activity and contraction of diabetes, with risk reductions of 33-5
0% recorded for active groups .Walking, cycling and active hobbies such as gardening are associated with lower risk but it is likely that the greatest gains are made with moderate to vigorous activity. The strong relationship is plausible as the muscle is a critical site for glucose metabolism.

Exercise has been shown to delay or possibly prevent progression of glucose intolerance to the diagnosis of diabetes. Exercise also has benefits for those who are already diagnosed with diabetes. A small number of well designed studies have also shown that an activity program of walking or cycling, carried out three times a week for 30-40 minutes, is able to produce small but significant improvements in glycemic control in diabetics.

Cancer
Involvement in occupational or leisure time physical activity carries a reduced risk of mortality from cancer a leading cause of ill health and death. Moderate to vigorous activity appears to be most beneficial. The strongest protective effect is for colon or colorectal cancers producing a 40-50% risk reduction.
Physical activity also helps prevent lung cancer with a 40% risk reduction evident after control for smoking and other lifestyle factors. Similarly there are benefits for breast cancer but not prostate or testicular cancer.
There has been less attention paid to the impact of exercise in the treatment or management of cancer. Although there is as yet insufficient evidence to suggest that progress of the disease can be slowed by exercise, it does appear to have benefits for life quality including improved psychological well-being and reductions in fatigue and nausea.
Bone and muscle health
Diseases such as low back pain, osteo-arthritis and osteoporosis are a major cause of human suffering, reduced life quality and lost work productivity. Exercise training produces stronger muscles, tendons and ligaments and thicker more dense bone which improves functional capacity and allows greater independent living in older people. Physical activity programs designed to improve muscular strength also helps older adults to maintain balance and a reduction in falls. It can be effective in preventing low back pain and also reduces reoccurrence of back problems. Physical activity has not been shown to prevent osteo-arthritis but walking programs have indicated important beneficial effects. Exercise can reduce pain, stiffness and disability and improve strength, mobility and overall ratings of life quality.
Exercise training involving, weight bearing moderate to vigorous activity, can increase bone mineral density and bone size in adolescents, help maintain it in adults and slow decline in older age. This in turn prevents or delays the onset of osteoporosis but cannot reverse osteoporosis once it has developed. The effect is specific to those bones loaded by the exercise.
Mental well-being
The case for physical activity and health has largely been made on the evidence for its prevention of diseases such as CHD, cancer, obesity and diabetes. The World Health Organization has estimated that mental illness, largely in the form of depression and anxiety, will be the leading cause of disability and a major cause of loss of life by the year 2020. In addition to increased incidence of serious mental illness there is concern for the increasing numbers who suffer chronic or recurrent mild to moderate symptoms of depression. Several well designed studies have now shown that physical activity can reduce clinical depression.
Exercise can be as effective as traditional treatment such as psychotherapy as it can offer a cheap alternative. Physical activity also improves psychological well-being in those who are not suffering from serious mental disorders. Several hundreds of studies have documented improvements in subjective well-being, mood and emotions, and self-perceptions such as body image, physical self-worth and self-esteem. Furthermore, both single bouts of activity and exercise training reduce anxiety stresses, and also improve quality and length of sleep.
Physical activity is particularly helpful for older people as it reduces risk of dementia and Alzheimer disease and improves executive aspects of mental functioning such as planning, short-term memory and decision making. Clearly, physical activity has tremendous potential to improve quality of life throughout the lifespan.
Risks of physical activity
The risk of sudden cardiac death is elevated by five times during vigorous exercise for fit individuals and 56 times for unfit individuals. Any risks accompanying exercise are far outweighed by the benefits and the reductions in disease risk that fitness brings. There is also an increased risk of injury, particularly to feet, ankles and knees, while taking part in exercise or vigorous sports.
Physical activity recommendations
When people become more active, they reduce their risk of early death from heart disease, some cancers and diabetes. They manage their weight better, increase their tolerance for physical work, and they improve their muscle and bone health. They are also likely to improve their psychological well-being and life quality. And, physical activity has the potential to add years to life.
For many years, exercise and health promoters adopted training guidelines for the improvement of cardiovascular fitness involving vigorous exercise using large muscle groups in continuous work for a minimum of 20 minutes at an intensity equivalent to 60-80% of maximum heart rate. Unfortunately, after almost two decades of promoting this there has been little increase in the people exercising at this level. It seems that it is too rigorous for most people. The evidence also indicates that it is not essential to work so hard in order to appreciate health gains. There is a curve of diminishing returns regarding physical activity level and health benefit with the greatest gains to be made by individuals changing from the sedentary to moderately active category.
The physical activity promotion message is now to take regular activity of a moderate intensity, equivalent to brisk walking, is thought to be achievable by a much larger percentage of the population as it can be reasonably incorporated into daily routines and is less physically demanding. Current recommendations emphasize brisk walking on most or all of the days of the week for 30 minutes at a time, even when the same amount is taken in two or three shorter bouts.
This is essentially a general recommendation. Different types and intensities of activity will improve different elements of health and fitness. For example, a gentle stroll at lunchtime, although not sufficiently intensive to create an improvement in circulatory fitness, may provide a healthy break from work, enhance mood and reduce stress, while also contributing to weight management. The accumulation of small but regular periods of movement during work or leisure can also make a significant difference to energy balance and weight control in the long term. Simply standing for one hour instead of sitting watching TV each day, for example, will expend the equivalent of 1 - 2 kgs of fat per year. A daily 20-minute brisk walk will make a difference of 5 kgs per year, and for most people there will be improvements in cardiovascular fitness and potential for other physical and mental health benefits.

There may also be a benefit in reducing the amount of time spent in sedentary persuits such as watching television. To provide maximum benefits for all areas of the body, a range of specific strengthening and stretching exercises will also be needed. This is particularly important for older people.




  • Involve large muscle groups

  • Impose more than a customary load

  • Require a minimum total of 700 kcal/week

  • Be performed regularly and if possible daily

In practice, sustained rhythmic exercise, such as brisk walking for 20-30 minutes would fulfill this requirement in most adults.

For further maximum health benefits, activities should:

  • Include some periods of vigorous activity

  • Include a variety of activities

  • Exercise most of the body’s muscles, including trunk and upper body

  • Expend up to 2000 kcals/week

  • Be maintained throughout life

Calisthenics
The Japanese work ethic includes some calisthenics (mild physical exercise) during the workday. They believe the workout helps promote productivity. Some American companies are studying the validity of the relationship, but a few firms are not exactly convinced. This sign was posted on a company bulletin board: “This firm requires no physical fitness program. Everyone gets enough exercise jumping to conclusions, flying off the handle, running down the boss, flogging dead horses, knifing friends in the back, dodging responsibility, and pushing their luck.”
Energy Used in Activities – (Use this guide to obtain an approximation of the calories you burn daily compared to the calories you ingest. If input consistently exceeds output, you need to burn more calories.)
Calories burned by a 130-lb person performing the following activities for an hour:


Around the house –
Mopping floor – 224
Cleaning windows – 216
Washing dishes – 168

Cooking – 164
Doing laundry – 156
Dusting – 148
Making a bed – 144
Ironing – 116
Talking on phone – 88
Sleeping – 72
Pleasure –
Walking dog – 284
Pushing baby stroller – 228
Gardening – 200
Baking cookies – 128
Writing a love letter – 104
Holding hands – 80
Reading a book – 76
Watching TV – 76
At Work
Strolling – 124
Writing at desk – 104
Sports
Bowling – 250
Golf – 230
Swimming, ¼ mph – 270
Volleyball – 320
Roller skating – 320
Bicycling 5 ½ mph – 190
Chores
Mowing lawn – 396
Shoveling dirt – 372
Painting outside – 272
Weeding – 252
Raking leaves – 192
Painting inside – 120
Others
Running – 420
Climbing hill – 360
Walking moderate – 180
Walking fast – 270
Driving car – 160
Standing – 100


Sharpening pencil – 104
Writing at desk – 104
Typing (electric) – 96
Attending a meeting – 72
Diet and Exercise Prolongs Life
Very recently two new studies based on a large U.S. diet and health survey demonstrate the benefits of exercise and diet in reducing health risks and prolonging life.
The first shows people who follow a Mediterranean-style diet rich in vegetables, fruits, whole grains, and healthy oils, such as those found in fish, olives, and nuts, were less likely to die of cancer, heart disease, or any other cause over a five-year period.
The second shows people who engaged in moderate exercise like walking for at least 30 minutes a day most days of the week, as recommended by national guidelines, were 27% less likely to die during the study than non-exercisers. Even a smaller amount of exercise produced benefits in reducing the risk of death over the short-term, but those healthy benefits increased with more frequent and vigorous exercise.
The studies, published in the Archives of Internal Medicine, were both based on data collected from the National Institutes of Health-AARP Diet and Health Study involving 566,407 AARP members aged 50 to 71 in six U.S. states who filled out diet and exercise questionnaires between 1995 and 1996.
In the first study, researchers looked at the effect of the Mediterranean diet on the risk of death over five years. This diet has gained in popularity in recent years thanks to research that shows countries that follow the diet, rich in fruit and vegetables and low in saturated fat, have lower rates of heart disease and other health problems. This study confirmed those healthy effects and showed men and women who followed a Mediterranean diet were 20% less likely to die from any cause during the study.
In the second study, researchers compared the risk of dying during the study to rates of exercise. The results showed that people who were moderately active for at least 30 minutes a day, most days of the week were 27% less likely to die than those that were inactive. The health benefits of exercise increased with more vigorous activity. Those who engaged in vigorous activity had a 32% lower risk of death during the study; a level of physical activity that was less than recommended was linked to a 19% lower death risk.
One final benefit in becoming active – you save on electricity bills when the TV is switched off while doing the chores.

Sunday, December 16, 2007

Cheaper Medicines Bill

Cheaper Medicines Bill

For lack of quorum in the waning weeks of the House, 13th Congress, the Cheaper Medicines legislation was killed. Retrieving the Bill, its successor the 14th Congress is attempting to pass the legislation before the 2007 Christmas break, raising some anxiety and stress to the eagerly awaiting ill and hypochondriac pill-poppers. The obstacles delaying passage are the debates, lobbying of all-powerful Big Pharma and even from the medical community
Debate on cheaper meds
Philippine College of Physicians (PCP) expressed, in a full-page advertisement, their unqualified support for the efforts to bring down the cost of medicines. (Inquirer, 11/25/07) but fears about the effects of a Cheaper Medicine law on therapeutic efficacy and safety. PCP’s argument—that making medicines affordable would undermine drug safety and efficacy, and avers the bill promotes practice-of-medicine-at-the-drugstore-counter.
Medical Action Group Inc. (MAG) disputes the PCP claims. They allege the World Health Organization (WHO) has been actively campaigning for the use of generic equivalent to medical treatment, even encouraging physicians to issue prescriptions using generic names only. The Cheaper Medicine bill seeks to address the lack of affordable medicines for Filipinos, not replace the physicians’ authority and responsibility in determining the appropriate and safe treatment for their patients. The fact is that one of the reasons why most Filipinos have not followed prescribed treatment is because of their incapacity to buy prescribed medicines. Statistical data show that in 2006, a meager 2.9 percent is being spent on medical care by a Filipino family.
Don’t count your chicks yet, folks. The bill may not be potent enough to neutralize the deviousness of Big Pharma and its cohorts in the medical community. Are there other means to maintain public health? You bet!
Chronic (non-communicable) diseases and practice of prevention is preferable to the current paradigm of ‘popping pills’, the modern conventional medicine. It’s much cheaper and less stressful. Medical science knows that 80% of chronic non-communicable disease (heart disease, strokes, diabetes, high blood pressure and cholesterol) and 30% of cancer can be prevented with proper diet, physical activity and avoidance of tobacco.
Pending the promulgation of the provisions of the so-called Cheaper Medicines Bill it is premature to comment on its merits. But one contentious item in the debates that is disturbing is the setting up of a Drug Price Regulatory Board for its potential to boost corruption. An editorial speculating on the acrimonious debates foresees a watered down version. This would be a pity, a waste of valuable resource. Water is too precious to waste for watering down feeble and ineffective bills purporting to boost public healthcare. Public health policy must focus on protecting the health of the teeming healthy public and preventing disease, both the infectious and the chronic non-communicable type (yes, they are preventable). Suggestion: ensure sustained supplies of clean water and safe food (restrain junk and unhealthy food); use water to wash hands and food to avoid diarrhea and obviate the need to buy medicine.
Chronic (non-communicable) diseases—including cardiovascular diseases, cancer, chronic respiratory diseases, and diabetes—are leading causes of death and disability but are neglected elements of the global-health agenda, and, not surprisingly, this includes the Philippines. WHO has proposed a global goal for the prevention and control of chronic diseases to complement the Millennium Development Goals. A British medical journal, the Lancet, published a five part series in pursuing the goal. “Achievement of the global goal would avert 36 million deaths by 2015. Furthermore, because most of the averted deaths would be in low-income and middle-income countries and about half would be in people younger than 70 years, it would have major economic benefits, including extension of productive life and reduction in the need for expensive care.”
Joining the chorus, several of the world's most eminent health scientists and organizations have published, in their study featured in Nature magazine, a landmark global consensus on the 20 foremost measures needed to curb humanity's most fatal diseases, Known as chronic, non-communicable diseases, they are reaching world epidemic proportions and include cardiovascular diseases (mainly heart disease and stroke), several cancers, chronic respiratory conditions, and type 2 diabetes.
In their paper for Nature, the 19 authors say chronic non-communicable diseases:

  • Cause the greatest share of death and disability worldwide;

  • Account for over 60% of deaths worldwide, four-fifths of those fatalities being citizens of low and middle income countries;

  • Cause twice as many deaths as the combined total of HIV/AIDS, tuberculosis, malaria, maternal and pre-natal conditions, and nutritional deficiencies.

CNCDs, defined by the WHO as cardio-vascular disease, type 2 diabetes, chronic respiratory diseases and certain cancers, are largely preventable. It's estimated that eliminating key risk factors (poor diet, physical inactivity, smoking) would prevent 80% of heart disease, strokes and type 2 diabetes, and over 40% of cancer cases.

The initiative's leaders say their goals are "to galvanize the health, science and public policy communities into action on this epidemic," and to foster global debate, support and funding.

The Grand Challenges are grouped under six broad goals: (The Lancet proposal is essentially similar)

  • Reorient health systems (e.g. Grand Challenge: "Allocate resources within health systems based on burden of disease");

  • Mitigate health impacts of poverty and urbanization (e.g.: "Study and assess how poverty increases risk factors");

  • Engage businesses and community (e.g.: "Make business a key partner in promoting health and preventing disease; Develop and monitor codes of responsible conduct with the food, beverage and restaurant industries");

  • Modify risk factors (e.g.: "Deploy universally measures proven to reduce tobacco use and boost resources to implement the WHO framework Convention on Tobacco Control");

  • Enhance economic, legal and environmental policies (e.g. "Study and address the impacts of poor health on economic output and productivity"); and

  • Raise public and political awareness (e.g.: "Promote healthy lifestyle and consumption choices through effective education and public engagement").

While these challenges are applicable to all countries, different nations should identify local priorities from among those identified here for immediate attention, depending on resources and disease Inaction is costing millions of premature deaths throughout the world offsetting the gains from a decreasing burden of infectious diseases. “In developing countries, many beset by infectious diseases, authorities have not resourced or thought through the policy implications of addressing these silent killers. But that's like putting out one fire in a house burning from both ends," says one scientist.

Lifestyle Changes

An American health journal summarizes the lifestyle choices you should do to help prevent chronic diseases, such as diabetes, heart disease, stroke respiratory and certain types of cancer. If you have such disease or are at high risk to develop it, you should do the following:

  • Eat plenty of vegetables and fruits while avoiding trans fats and saturated fats.

  • Keep blood pressure in the normal range, ideally with a systolic blood pressure of less than 120 millimeters of mercury (mm Hg).




  • Don't smoke.

  • Strive to keep your blood sugar levels normal.

  • Manage stress.

  • Become more physically active, and make daily exercise a priority at an intensity level recommended by your doctor.

High LDL cholesterol is one of the major risk factors for heart disease, and the risk increases as the bad cholesterol level rises. Other major risk factors are smoking, high blood pressure and diabetes. Your cholesterol level is determined by your genetic makeup and the amount of saturated fat and cholesterol in the foods you eat. The liver manufactures cholesterol, so even if you never eat cholesterol, your body can make all it needs.

Several factors contribute to high blood cholesterol:

Diet: Reduce your blood LDL cholesterol level by eating less fat, particularly saturated fat (as found in whole milk, cheese and meat). Low cholesterol foods are important, too. Studies have shown that your total cholesterol and your bad cholesterol levels may begin to drop two to three weeks after you begin your lower you intake of fat, calories and cholesterol.

A healthy diet:

  • Contains healthy fats. Once you've cut way back on saturated fats and trans fats (the unhealthy fats), you can start adding healthy fats to your diet. Healthy fats are polyunsaturated and monounsaturated.

  • Contains healthy sources of carbohydrates. Eat more whole grains — foods like whole-wheat bread, brown rice and oatmeal — to help lower cholesterol, improve blood sugar and insulin levels, control weight, protect the heart, guard against diabetes and keep your digestive system healthy.

  • Relies on healthy sources of protein. For a healthier heart, cut back on red meat and switch to fish. The good fats in many types of fish help protect the heart against erratic rhythms and may prevent blood clots. Wild-range fish are preferable to farmed fish. The American Heart Association recommends that people eat fish (especially fatty fish) at least two times per week. Beans, nuts and seeds are also excellent sources of protein.

  • Includes plenty of fruits, vegetables and whole grains. These foods have more powerful effects on your health than most pills.

  • Tastes great. If it doesn't, you probably won't stick with it for long.

Weight control: Obesity increases triglyceride and total blood cholesterol levels, blood pressure and the risk of developing diabetes.

Exercise: Regular exercise or continuous physical activity may help a person control weight, lower blood pressure and increase the level of high-density lipoprotein, or HDL (good), cholesterol.

Genetic factors: Understand that lowering your LDL cholesterol levels through diet often is not enough to reach your goal. Many people are genetically programmed to produce cholesterol in the liver no matter how strictly they follow a diet.

Sex/age: Coronary heart disease is the leading cause of death and disability for both men and women in the United States. Traditionally, coronary heart disease has been associated much more with older men than women. However, today, the importance of lifestyle changes is recognized for both sexes at all ages.

Alcohol: In some people, modest amounts of alcohol can increase the amount of good cholesterol (HDL). Modest intake means two or fewer drinks per day for men and one drink per day for women. There is good evidence that moderate alcohol intake lowers the risk of coronary artery disease, whether or not the protection is due to increasing HDL levels. However, alcohol provides "empty calories" that can add to your weight, and because drinking can have serious adverse effects, present guidelines do not recommend drinking alcohol as a way to prevent heart disease.

Smoking: Smoking damages the heart by raising blood pressure, damaging blood vessels, promoting the buildup of fatty plaque in arteries, lowering levels of "good" cholesterol, making the blood more likely to clot and depriving the heart of oxygen. Quitting smoking is the best thing you can do to prevent a heart attack.

Stress: Stress can increase chemicals within the body that may increase the risk of a heart attack. These fight-or-flight stress hormones, such as cortisol and epinephrine, excite the heart and make it work overtime.

The Lancet provides evidence that this goal is not only possible but also realistic. The major drawback is that it requires the cooperation and coordination of many sectors of society, unprecedented in contemporary Philippine milieu. But a city in the U.S., unaware of the Lancet agenda, is actually undertaking an experiment with the similar goal of preventing chronic disease

Heart-disease prevention target of Baltimore plan

Churches, barbershops and other unlikely allies would take part in a communitywide assault on heart disease proposed by the Baltimore City and Baltimore County health officers. The plan focus will be on simple measures known to prevent the disease or lessen its impact. These include smoking cessation, low-salt diets, exercise and taking medications as prescribed and recommending lifestyle changes to make better food choices on a daily basis The proposal, which is a set of principles and suggestions, has been under development for about a year and is the product of meetings with public health experts. The health officers have posted the proposal on the Internet and are inviting people to submit ideas. Public hearings are scheduled.



Elements of the proposal were borrowed from other cities and countries. Some represent programs that had brief stints in Baltimore. The Johns Hopkins School of Medicine ran a program called Heart, Body and Soul between 1998 and 2002 that involved churches in the promotion of healthy lifestyles. The proposal calls for the recruitment of churches and other faith-based institutions to sponsor health screenings and prevention programs. It also calls for the training of laypeople to become "community health workers" who could accompany patients to medical appointments, refer them to social services and administer blood pressure tests. It also envisions an expansion of the number of barbershops and beauty parlors involved in blood-pressure screening.



The proposal calls for the formation of a task force that would consider ways to get restaurants, grocers and food manufacturers to reduce their use of salt. Several countries, including England, Ireland, New Zealand, Australia and Finland, have reduced dietary salt through voluntary measures or labeling requirements.



The plan keeps an open option as to whether to seek voluntary salt reductions or impose rules on restaurants and food manufacturers. This year, New York prohibited restaurants from cooking with anything more than minute amounts of trans fats, substances implicated in heart disease. A Hopkins professor of medicine and public health who ran the Heart Body and Soul program, said prevention programs inevitably compete with a fast-food industry that propagandizes people to eat unhealthy foods.

Filibuster

Back to the progress of the Bill, Congress has only a few more days before their X’Mas vacation and tensions are building up. Congressman Pablo Garcia is unrelenting in blocking passage to a law he asserts is under lobby by Big Pharma, is a farcical placebo. MalacaƱan is cornered into a quandary, what move to take: support or veto a law that mandates lower prices for placebos?